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Molecular Mechanisms of Dementia true
By:Wilma Wasco,Rudolph Tanzi
Published on 1996-11-01 by Springer Science & Business Media

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. |Late onset| (\u003e60 yr) cases, which account for the vast majority of AD, genetically involve |susceptibility| genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a |modifier| that modulates the pathogenic cascade occurring subsequent to a separate etiological event |initiating| or |causing| the disorder.

This Book was ranked at 4 by Google Books for keyword Dementia.

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Book which was published by Springer Science & Business Media since 1996-11-01 have ISBNs, ISBN 13 Code is 9781592594719 and ISBN 10 Code is 1592594719

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